Human Genetics

, Volume 73, Issue 1, pp 77–80

The genes for human gastrin and cholecystokinin are located on different chromosomes

Authors

  • T. Lund
    • Iniversity Department of Clinical Chemistry 6321Rigshospitalet
  • A. H. M. Geurts van Kessel
    • Department of Cell Biology and GeneticsErasmus University
  • S. Haun
    • Department of BiochemistryPurdue University
  • J. E. Dixon
    • Department of BiochemistryPurdue University
Original Investigations

DOI: 10.1007/BF00292669

Cite this article as:
Lund, T., Geurts van Kessel, A.H.M., Haun, S. et al. Hum Genet (1986) 73: 77. doi:10.1007/BF00292669

Summary

The polypeptide hormones gastrin and cholecystokinin are structurally related, having the identical pentapeptide GWMDF located at their C-terminus. The precursors to these two hormones also show amino acid homology, suggesting that they may have a common ancestral origin. Recombinant DNA clones corresponding to gene fragments encoding human gastrin and cholecystokinin were used to determine their respective chromosomal localization by analyzing human-rodent cell lines. We have assigned the cholecystokinin gene to human chromosome 3q12-3pter and the gastrin gene to chromosome 17q.

Copyright information

© Springer-Verlag 1986