Human Genetics

, Volume 73, Issue 1, pp 17–19

Assignment of the human γ-crystallin gene cluster (CRYG) to the long arm of chromosome 2, region q33–36

  • Y. Shiloh
  • T. Donlon
  • Gail Bruns
  • M. L. Breitman
  • Lap-Chee Tsui
Original Investigations

DOI: 10.1007/BF00292656

Cite this article as:
Shiloh, Y., Donlon, T., Bruns, G. et al. Hum Genet (1986) 73: 17. doi:10.1007/BF00292656

Summary

The γ-crystallins of the human eye lens are encoded by a multigene family of which at least six genes have recently been assigned to chromosome 2. We have now localized these genes to the distal region of the long arm of chromosome 2 (region q33-36, most probably q34-35) using somatic cell hybrids containing different parts of this chromosome and by in situ hybridization. The γ-crystallin genes map to the same chromosomal region as IDH-1. Similar linkage exists between the loci Len-1 and Idh-1 on mouse chromosome 1.

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • Y. Shiloh
    • 1
  • T. Donlon
    • 1
  • Gail Bruns
    • 1
  • M. L. Breitman
    • 2
    • 3
  • Lap-Chee Tsui
    • 2
    • 3
  1. 1.Mental Betardation Center and Genetics Division, Children's Hospital and Department of PediatricsHarvard Medical SchoolBostonUSA
  2. 2.Department of GeneticsThe Hospital for Sick ChildrenTorontoCanada
  3. 3.Department of Medical Genetics and Medical BiophysicsUniversity of TorontoTorontoCanada
  4. 4.Department of Human Genetics, The Sackler Faculty of MedicineTel-Aviv UniversityRamat AvivIsrael
  5. 5.Division of Cancer ResearchMount Sinai HospitalOntarioTorontoCanada