Mammalian Genome

, Volume 5, Issue 12, pp 749–755

Assignment of a locus for mouse lung tumor susceptibility to proximal Chromosome 19

  • T. R. Devereux
  • R. W. Wiseman
  • N. Kaplan
  • S. Garren
  • J. F. Foley
  • C. M. White
  • C. Anna
  • M. A. Watson
  • A. Patel
  • S. Jarchow
  • R. R. Maronpot
  • M. W. Anderson
Original Contributions

DOI: 10.1007/BF00292007

Cite this article as:
Devereux, T.R., Wiseman, R.W., Kaplan, N. et al. Mammalian Genome (1994) 5: 749. doi:10.1007/BF00292007

Abstract

Previous studies have hypothesized that at least three genetic loci contribute to differences in pulmonary adenoma susceptibility between mouse strains A/J and C57BL/6J. One gene that may confer susceptibility to lung tumorigenesis is the Kras protooncogene. To identify other relevant loci involved in this polygenic trait, we determined tumor multiplicity in 56 randomly chosen N-ethyl-N-nitrosourea-treated (A/J×C57BL/6J) N1×C57BL/6 backcross (AB6N2) progeny and correlated it with genotypes at 77 microsatellite markers spanning the genome. A correlation of lung tumor multiplicity phenotypes with genotypes of microsatellite markers on distal Chromosome (Chr) 6 in the Kras region (Pas1) was confirmed, and a new region on Chr 19 (designated Pas3) was identified that also contributes to susceptibility. Linkage analysis on Chr 19 with 270 AB6N2 mice localized the region flanked by D19Mit42 and D19Mit19 that is most closely associated with lung tumor susceptibility. The Pas3 locus may be an enhancer of the susceptibility locus on Chr 6.

Copyright information

© Springer-Verlag New York Inc. 1994

Authors and Affiliations

  • T. R. Devereux
    • 1
  • R. W. Wiseman
    • 1
  • N. Kaplan
    • 1
  • S. Garren
    • 1
  • J. F. Foley
    • 1
  • C. M. White
    • 1
  • C. Anna
    • 1
  • M. A. Watson
    • 1
  • A. Patel
    • 1
  • S. Jarchow
    • 1
  • R. R. Maronpot
    • 1
  • M. W. Anderson
    • 1
  1. 1.Environmental Carcinogenesis Program and Experimental ProgramNational Institute of Environmental Health SciencesResearch Triangle ParkUSA
  2. 2.St. Mary's HospitalGrand JunctionUSA

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