Human Genetics

, Volume 72, Issue 3, pp 262–265

Assignment of the human homologue of Pim-1, a mouse gene implicated in leukemogenesis, to the pter-q12 region of chromosome 6

  • H. T. Cuypers
  • G. Selten
  • A. Berns
  • A. H. M. Geurts van Kessel
Original Investigations

DOI: 10.1007/BF00291892

Cite this article as:
Cuypers, H.T., Selten, G., Berns, A. et al. Hum Genet (1986) 72: 262. doi:10.1007/BF00291892

Summary

Viral leukemogenesis in mice is frequently initiated by proviral activation of a highly conserved cellular gene called Pim-1. Here we report the chromosomal localization of the human homologue by Southern blot analyses of DNAs obtained from human-rodent somatic cell hybrids. The single copy human homologue was assigned to the 6pter-q12 segment.

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • H. T. Cuypers
    • 1
  • G. Selten
    • 1
  • A. Berns
    • 1
  • A. H. M. Geurts van Kessel
    • 2
  1. 1.Department of BiochemistryUniversity of NijmegenNijmegenThe Netherlands
  2. 2.Department of Cell Biology and GeneticsErasmus UniversityRotterdamThe Netherlands
  3. 3.Department of Molecular BiologyThe Netherlands Cancer InstituteAmsterdamThe Netherlands
  4. 4.Department of Molecular BiologyThe Netherlands Cancer InstituteAmsterdamThe Netherlands