Human Genetics

, Volume 78, Issue 1, pp 90–93

Apolipoprotein gene cluster on chromosome 19

Definite localization of the APOC2 gene and the polymorphic Hpa I site associated with type III hyperlipoproteinemia
  • Marijke Smit
  • Ellien van der Kooij-Meijs
  • Rune R. Frants
  • Louis Havekes
  • Eduard C. Klasen
Short Communications

DOI: 10.1007/BF00291243

Cite this article as:
Smit, M., van der Kooij-Meijs, E., Frants, R.R. et al. Hum Genet (1988) 78: 90. doi:10.1007/BF00291243

Summary

Recently, using an APOE cDNA probe, we discovered an Hpa I restriction fragment length polymorphism (RFLP) that appeared to be strongly associated with the expression of type III hyperlipoproteinemia (Klasen et al. 1987). In the present report it is shown that the same Hpa I RFLP can be revealed with both the APOC1 and APOC2 cDNA probes. This enabled us to localize the polymorphic Hpa I site between the APOE and APOC1 genes and to localize the APOC2 gene approximately 22 kb 3′ of the APOC1 pseudogene on chromosome 19.

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Marijke Smit
    • 1
  • Ellien van der Kooij-Meijs
    • 1
  • Rune R. Frants
    • 3
  • Louis Havekes
    • 2
  • Eduard C. Klasen
    • 1
  1. 1.Department of Human GeneticsSylvius LaboratoriesLeidenThe Netherlands
  2. 2.Health Research Division TNOGaubius InstituteLeidenThe Netherlands
  3. 3.Institute of Human GeneticsFree UniversityAmsterdamThe Netherlands