The Duffy blood group is linked to the α-spectrin locus in a large pedigree with autosomal dominant inheritance of Charcot-Marie-Tooth disease type 1
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- Raeymaekers, P., Van Broeckhoven, C., Backhovens, H. et al. Hum Genet (1988) 78: 76. doi:10.1007/BF00291239
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The α-spectrin locus (SPTA) on chromsome 1 maps to 1q22–q25 and α-spectrin specific probes detect restriction fragment length polymorphisms (RFLPs) with the endonucleases MspI and PvuII. The Duffy blood group (FY) has been mapped to the 1p21–q23 region. We found positive linkage between the α-spectrin and the Duffy loci with a maximal Lod score of 3.81 at θ=0.0 using the computer program MLINK. This indicates that both loci are very closely linked and probably localized to 1q22–q23.