Human Genetics

, Volume 78, Issue 1, pp 47–50

Genetics of the quantitative Lp(a) lipoprotein trait

II. Inheritance of Lp(a) glycoprotein phenotypes
  • Gerd Utermann
  • Christoph Duba
  • Hans Jürgen Menzel
Original Investigations

DOI: 10.1007/BF00291233

Cite this article as:
Utermann, G., Duba, C. & Menzel, H.J. Hum Genet (1988) 78: 47. doi:10.1007/BF00291233

Summary

Lp(a) glycoprotein exhibits an apparent size polymorphism that is associated with genetically controlled Lp(a) lipoprotein concentrations in plasma (Utermann et al. 1988). We have tested the hypothesis that this polymorphism is genetically controlled by studying 15 matings with a total of 44 offspring. This confirmed our conclusion that Lp(a) types are controlled by a series of codominant alleles LpF, LpB, LpS1, LpS2, LpS3 and LpS4 and by a null allele Lpo. Together with the data from the accompanying paper this indicates that the structural gene for the Lp(a) protein is the major gene locus determining Lp(a) lipoprotein concentrations in plasma.

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Gerd Utermann
    • 1
  • Christoph Duba
    • 1
  • Hans Jürgen Menzel
    • 1
  1. 1.Institut für Medizinische Biologie und Genetik der UniversitätInnsbruckAustria

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