, Volume 72, Issue 4, pp 352-353

The gene encoding for the major brain proteolipid (PLP) maps on the q-22 band of the human X chromosome

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Summary

Recombinant plasmid clone p23 containing the cDNA proteolipid (PLP) sequence was localized by in situ hybridization on band q22 of the human X chromosome. This localization may have implications for X-linked demyelination diseases such as Pelizacus-Merzbacher disease in man.