Diabetologia

, Volume 31, Issue 4, pp 225–227

Absence of glucopenic inhibition of the insulin response to arginine at the onset of diabetes in BB/W rats

  • I. Komiya
  • R. H. Unger
Originals

DOI: 10.1007/BF00290589

Cite this article as:
Komiya, I. & Unger, R.H. Diabetologia (1988) 31: 225. doi:10.1007/BF00290589

Summary

To determine if the inhibiting effect of glucopenia on arginine-stimulated insulin secretion is impaired at the onset of autoimmune diabetes, the insulin response to arginine was studied at 5.6 and 2.8 mmol/l glucose in perfused pancreata isolated from BB/W rats on the first day of diabetes and from age-matched diabetes-prone BB/W rats without diabetes. During glucopenia the baseline insulin secretion was reduced by more than 80% in both groups. However, the arginine-stimulated insulin response in the diabetic group was only 16.5% lower during glucopenia compared to 79.1% lower in the nondiabetic controls. Also, enhancement of the arginine-stimulated glucagon response by glucopenia was modest compared to controls. The results indicated that at the onset of this form of autoimmune diabetes the surviving B cells are, for unknown reasons, hyperresponsive to arginine and that, in contrast to the controls, this response is not inhibited by glucopenia.

Key words

GlucopeniainsulinglucagonargininediabetesBB/W ratsperfused pancreas

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • I. Komiya
    • 1
    • 2
  • R. H. Unger
    • 1
    • 2
  1. 1.Center for Diabetes ResearchUniversity of Texas Health Science Center, the Veterans Administration Medical CenterUSA
  2. 2.The Department of Internal MedicineUniversity of Texas Southwestern Medical SchoolDallasUSA