Originals

Diabetologia

, Volume 31, Issue 4, pp 225-227

First online:

Absence of glucopenic inhibition of the insulin response to arginine at the onset of diabetes in BB/W rats

  • I. KomiyaAffiliated withCenter for Diabetes Research, University of Texas Health Science Center, the Veterans Administration Medical CenterThe Department of Internal Medicine, University of Texas Southwestern Medical School
  • , R. H. UngerAffiliated withCenter for Diabetes Research, University of Texas Health Science Center, the Veterans Administration Medical CenterThe Department of Internal Medicine, University of Texas Southwestern Medical School

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Summary

To determine if the inhibiting effect of glucopenia on arginine-stimulated insulin secretion is impaired at the onset of autoimmune diabetes, the insulin response to arginine was studied at 5.6 and 2.8 mmol/l glucose in perfused pancreata isolated from BB/W rats on the first day of diabetes and from age-matched diabetes-prone BB/W rats without diabetes. During glucopenia the baseline insulin secretion was reduced by more than 80% in both groups. However, the arginine-stimulated insulin response in the diabetic group was only 16.5% lower during glucopenia compared to 79.1% lower in the nondiabetic controls. Also, enhancement of the arginine-stimulated glucagon response by glucopenia was modest compared to controls. The results indicated that at the onset of this form of autoimmune diabetes the surviving B cells are, for unknown reasons, hyperresponsive to arginine and that, in contrast to the controls, this response is not inhibited by glucopenia.

Key words

Glucopenia insulin glucagon arginine diabetes BB/W rats perfused pancreas