, Volume 36, Issue 2, pp 204–210

The use of proteolytic enzymes for the mapping of structural rearrangements in the chromosomes of man

  • Marina Seabright

DOI: 10.1007/BF00285214

Cite this article as:
Seabright, M. Chromosoma (1972) 36: 204. doi:10.1007/BF00285214


Chromosome preparations treated for short periods with the proteolytic enzyme trypsin show well defined banding patterns, comparable to those obtained by more elaborate techniques.—With such patterns it is possible to map in detail the position of chromosome rearrangements.—A rare balanced A1–E18 translocation in a phenotypically normal female and the unbalanced product in her abnormal child has been used to demonstrate this mapping method.

Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • Marina Seabright
    • 1
    • 2
  1. 1.Department of ZoologyUniversity of SouthamptonUK
  2. 2.Department of Pathology Cytogenetics UnitGeneral InfirmarySalisburyEngland