Human Genetics

, Volume 83, Issue 3, pp 297–299

Assignment of the gene(s) involved in the expression of the proliferation-related Ki-67 antigen to human chromosome 10

  • D. M. Schonk
  • H. J. H. Kuijpers
  • E. van Drunen
  • C. H. van Dalen
  • A. H. M. Geurts van Kessel
  • R. Verheijen
  • F. C. S. Ramaekers
Short Communications

DOI: 10.1007/BF00285178

Cite this article as:
Schonk, D.M., Kuijpers, H.J.H., van Drunen, E. et al. Hum Genet (1989) 83: 297. doi:10.1007/BF00285178

Summary

The antigen recognized by the monoclonal antibody Ki-67 is a proliferation-related nucleolus-associated constituent used as a marker for cycling cells in tumor diagnosis. Antibody Ki-67 reacts with human proliferating cells, but not with hamster and mouse cells. Expression of the Ki-67 antigen was studied in a panel of human-rodent somatic cell hybrids. The results indicate that a gene involved in the expression of the antigen is located on chromosome 10.

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • D. M. Schonk
    • 1
  • H. J. H. Kuijpers
    • 2
  • E. van Drunen
    • 3
  • C. H. van Dalen
    • 1
  • A. H. M. Geurts van Kessel
    • 3
  • R. Verheijen
    • 2
  • F. C. S. Ramaekers
    • 2
  1. 1.Department of Human GeneticsUniversity Hospital of NijmegenNijmegenThe Netherlands
  2. 2.Department of PathologyUniversity Hospital of NijmegenNijmegenThe Netherlands
  3. 3.Department of Cell Biology and GeneticsErasmus UniversityRotterdamThe Netherlands