Original Investigations

Human Genetics

, Volume 57, Issue 2, pp 138-141

First online:

The genes for growth hormone and chorionic somatomammotropin are on the long arm of human chromosome 17 in region q21→qter

  • Donna L. GeorgeAffiliated withDepartment of Medicine, The Howard Hughes Medical Institute Laboratory for Human Biochemical Genetics
  • , John A. PhillipsIIIAffiliated withDepartment of Pediatrics, The Johns Hopkins School of Medicine
  • , Uta FranckeAffiliated withDepartment of Human Genetics, Yale University School of Medicine
  • , Peter H. SeeburgAffiliated withDepartment of Molecular Biology, Genentech, Inc.

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Summary

We used a cloned cDNA probe for human growth hormone and Southern blotting techniques to analyze DNA from a series of rodentxhuman somatic cell hybrids for the presence of growth hormone-related sequences. Our results provide evidence for the assignment of the genes for growth hormone and chorionic somatomammotropin as well as a growth hormone-like gene to human chromosome 17. Analysis of mousexhuman hybrid cells containing only part of the long arm of chromosome 17 enabled us to localize these genes to region 17q21→17qter.