Diabetologia

, Volume 28, Issue 7, pp 432–434

On the mechanism of the hypoglycaemic effect of a plant extract

  • F. M. Al-Awadi
  • M. A. Khattar
  • K. A. Gumaa
Originals

DOI: 10.1007/BF00280886

Cite this article as:
Al-Awadi, F.M., Khattar, M.A. & Gumaa, K.A. Diabetologia (1985) 28: 432. doi:10.1007/BF00280886

Summary

The efficacy of a hypoglycaemic plant extract, in common use by Kuwaiti diabetic individuals, was evaluated using both streptozotocin-induced diabetic and normal rats. A significant decrease in blood glucose concentration was demonstrated on glucose tolerance tests, as compared to untreated animals. The sum of the fasting, 1 and 2 h blood glucose values, decreased from 18.5±0.72 to 13.6±0.62mmol/l (p < 0.001) and from 58.6±2.83 to 44.5±3.12 mmol/l (p <0.005) in normal and diabetic animals treated for 1 week, respectively. Treatment with the extract was not found to significantly alter insulin levels or intestinal glucose absorption. The mode of action of the hypoglycaemic preparation remains to be elucidated.

Key words

Glucose tolerancestreptozotocindiabetes mellitusintestinal glucose absorptionhypoglycaemic extractouabainserum insulin

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • F. M. Al-Awadi
    • 1
  • M. A. Khattar
    • 1
  • K. A. Gumaa
    • 1
  1. 1.Departments of Biochemistry and Pharmacology, Faculty of MedicineKuwait UniversityKuwait