Human Genetics

, Volume 74, Issue 4, pp 447–448

Aberrant breakpoints in chronic myelogenous leukaemia; oncogenes and fragile sites

  • J. L. Huret
  • J. Tanzer
  • M. Henry-Amar
Original Investigations

DOI: 10.1007/BF00280504

Cite this article as:
Huret, J.L., Tanzer, J. & Henry-Amar, M. Hum Genet (1986) 74: 447. doi:10.1007/BF00280504

Summary

Three hundred and twenty-five aberrant breakpoints in chronic myelogenous leukaemia (CML) with Philadelphia chromosome variant were reviewed. Eight chromosomal bands (3p21, 6p21, 7p22, 11q13, 12p13, 17p13, 17q21, and 17q25) were found to be highly involved. Apart from 17q25, all these bands correspond to oncogenes sites and/or sites involved as primary breakpoints in cancer.

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • J. L. Huret
    • 1
  • J. Tanzer
    • 1
  • M. Henry-Amar
    • 2
  1. 1.Département d'Hématologie et Oncologie MédicaleHôpital Jean BernardPoitiers CedexFrance
  2. 2.Département de Statistique MédicaleInstitut Gustave RoussyVillejuif CedexFrance
  3. 3.Centre de Transfusion SanguinePoitiersFrance

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