Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
The effect of chronic administration of phosphatidylserine derived from brain cortex on the neuroendocrine responses to physical stress has been examined in a placebo-controlled study in 9 healthy men.
Phosphatidylserine 800 mg/d for 10 days significantly blunted the ACTH and cortisol responses to physical exercise (P=0.003 and P=0.03, respectively), without affecting the rise in plasma GH and PRL.
Physical exercise significantly increased the plasma lactate concentration both after placebo and phosphatidylserine.
The results suggest that chronic oral administration of phosphatidylserine may counteract stress-induced activation of the hypothalamo-pituitary-adrenal axis in man.
Supplementary Material (0)
- Axelrod J, Reisine TD (1984) Stress hormones: their interaction and regulation. Science 224: 452–459
- Bondar RJL, Mead DC (1974) Evaluation of glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides in the hexokinase method for determining glucose in serum. Clin Chem 20: 586–591
- Canonico PL, Scapagnini U (1989) Phosphatidylserine as a modulator of receptor-coupled signal transduction. In: Bazan NG, Horrocks LA, Toffano G (eds) Phospholipids in the nervous system: Biochemical and molecular pathology. Fidia Res Series, vol 17, Springer, Berlin Heidelberg New York, pp 11–20
- De Robertis E, Medina JH, Raskovsky S, Levi de Stein M, Wolfman C, Jerusalinsky D, Calvo D (1989) Action of in vivo phosphatidylserine on benzodiazepine and muscarinic receptors of rat brain. In: Bazan NG, Horrocks LA, Toffano G (eds) Phospholipids in the nervous system: biochemical and molecular pathology. Fidia Res Series, vol 17, Springer, Berlin Heidelberg New York, pp 35–42
- Gaillard RC, Al-Damluji S (1987) Stress and the pituitary-adrenal axis. Clin Endocrinol Metab 1: 319–354
- Hirata F, Haxelrod J (1980) Phospholipid methylation and biological signal transmission. Science 209: 1082–1090
- Monteleone P, Beinat L, Tanzillo C, Maj M, Kemali D (1990) Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans. Neuroendocrinol, 52: 243–248
- Nishizuka Y (1984) Turnover of inositol phospholipids and signal transduction. Science 225: 1375–1370
- Raese J, Patrick RL, Barchas JD (1976) Phospholipid induced activation of tyrosine hydroxylase from rat bran striatal synaptosomes. Biochem Pharmacol 25: 2245–2250
- Shinitzky M (1984) Membrane fluidity and receptor function. In: Membrane fluidity. Plenum Press, New York p 585–601
- Stockert M, Buscaglia V, De Robertis E (1989) In vivo action of phosphatidylserine, amitriptyline and stress on the binding of [3H]imipramine to membranes of the rat cerebral cortex. Eur J Pharmacol 160: 11–16
- Toffano G, Bruni A (1980) Pharmacological properties of phospholipid liposomes. Pharmacol Res Commun 12: 829–845
- Toffano G, Battistella A, Orlando P (1987) Pharmacokinetics of radiolabelled brain phosphatidylserine. Clin Trials J 24: 18–24
- Tuomisto J, Mannisto P (1985) Neurotransmitter regulation of anterior pituitary hormones. Pharmacol Rev 73: 249–332
- Vannucchi MG, Pepeu G (1987) Effect of phosphatidylserine on acetylcholine release and content in cortical slices from aging rats. Neurobiol Aging 8: 403–407
- Wheeler RP, Whittam R (1970) ATPase activity of the sodium pump needs of phosphatidylserine. Nature 225: 449–450
About this Article
- Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men
European Journal of Clinical Pharmacology
Volume 42, Issue 4 , pp 385-388
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- growth hormone
- Industry Sectors