European Journal of Clinical Pharmacology

, Volume 41, Issue 1, pp 65–68

Pharmacokinetics of intravenous and oral chlordesmethyldiazepam in patients on regular haemodialysis

  • J. Sennesael
  • D. Verbeelen
  • L. Vanhaelst
  • R. Pirola
  • S. R. Bareggi
Originals

DOI: 10.1007/BF00280109

Cite this article as:
Sennesael, J., Verbeelen, D., Vanhaelst, L. et al. Eur J Clin Pharmacol (1991) 41: 65. doi:10.1007/BF00280109

Summary

The pharmacokinetics of a single 2 mg IV dose of chlordesmethyldiazepam has been studied in 11 patients with renal failure on regular haemodialysis and in 11 age-matched healthy controls. The kinetics was also examined after a single 2 mg oral dose in 6 of the 11 renal failure patients.

After intravenous administration the kinetics of total chlordesmethyldiazepam in renal patients and controls were the same. The unbound fraction of the drug in renal patients was higher (5.5%) than in controls (2.9%). Correction for differences in protein binding revealed a reduced apparent volume of distribution (47 vs. 140 l · kg−1) and a reduced clearance (5.0 vs. 10.5 ml · min−1 · kg−1) in the patients. The systemic availability of oral chlordesmethyldiazepam was good (82%) despite a relatively slow absorption rate.

Key words

Chlordesmethyldiazepam pharmacokinetics i.v./p.o. administration renal failure protein binding pharmacodynamics 

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • J. Sennesael
    • 1
  • D. Verbeelen
    • 1
  • L. Vanhaelst
    • 2
  • R. Pirola
    • 3
  • S. R. Bareggi
    • 3
  1. 1.Department of Nephrology, Academisch ZiekenhuisVrije Universiteit BrusselsBelgium
  2. 2.Department of Pharmacology, Academisch ZiekenhuisVrije Universiteit BrusselsBelgium
  3. 3.Department of Pharmacology, Chemotherapy and Medical ToxicologyUniversità degli StudiMilanItaly