Pharmacokinetics of midazolam in critically ill neonates
Received: 02 October 1989 Accepted: 09 January 1990 DOI:
Cite this article as: Jacqz-Aigrain, E., Wood, C. & Robieux, I. Eur J Clin Pharmacol (1990) 39: 191. doi:10.1007/BF00280059 Summary
Midazolam is a water soluble benzodiazepine, with a short elimination half-life in adults and children. An IV bolus of midazolam 0.2 mg · kg
−1 was administered to 10 critically ill neonates receiving intensive care who required sedation.
The plasma clearance was 6.85 ml · min
−1 and the elimination half-life was 6.52 h. Midazolam was well tolerated during and after administration.
Because of its short half-life compared to diazepam, midazolam could be used during the neonatal period to produce brief rapid sedation.
Key words Midazolam Neonates Pharmacokinetics Sedation References
Anand KJS, Hickey PR (1987) Pain and its effects in the human neonate and foetus. N Engl J Med 9: 1321–1329
Willatts SM (1985) Intravenous sedation by infusion on the intensive care unit. Br J Parent Ther 1: 13–17
Farina ML, Levati A, Tognoni G (1981) A multi-center study of intensive care drug utilisation. Intensive Care Med 7: 125–131
Morselli PL, Principi N, Tognoni G, Reali E, Belvedere G, Standen S, Sereni F (1973) Diazepam elimination in premature and full-term infants and children. J Perinat Med 1: 133–141
Olive G, Rey E (1982) Pharmacocinétique comparée des benzodiazépines. Nouv Presse Med 11: 2957–2964
Reves JG, Fragen R, Vinik HR, Greenblatt DJ (1985) Midazolam: pharmacology and uses. Anesthesiology 62: 310–324
Saint-Maurice C, Meistelman C, Rey E, Esteve C, De Lauture D, Olive G (1986) The pharmacokinetics of rectal midazolam for premedication in children. Anesthesiology 65: 536–538
Booker PD, Beechey A, Lloyd-Thomas AR (1986) Sedation of children requiring ventilation using an infusion of midazolam. Br J Anaesth 58: 1104–1108
Puglisi CV, Pao J, Ferrara FJ, de Silva JAF (1985) Determination of midazolam (Versed) and its metabolites in plasma by high-performance liquid chromatography. J Chromatogr 344: 199–209
Allonen H, Ziegler G, Klotz U (1981) Midazolam kinetics. Clin Pharmacol Ther 30: 653–661
Payne K, Mattheyse FJ, Liebenberg D, Dawes T (1989) The pharmacokinetics of midazolam in paediatric patients. Eur J Clin Pharmacol 37: 267–272
Aranda JV, MacLeod SM, Renton KW, Eade NR (1974) Hepatic microsomal drug oxidation and electron transport in newborn infants. J Pediatr 85: 534–542
Guignard JP, Torrado A, Da Cunha O, Gautier F (1975) Glomerular filtration rate in the first weeks of life. J Pediatr 87: 268–272
Morselli PL, Franco-Morselli R, Bossi L (1980) Clinical pharmacokinetics in newborns and infants: age-related differences and clinical implications. Clin Pharmacokinet 5: 485–527