European Journal of Clinical Pharmacology

, Volume 39, Issue 2, pp 191–192

Pharmacokinetics of midazolam in critically ill neonates

  • E. Jacqz-Aigrain
  • C. Wood
  • I. Robieux
Short Communications

DOI: 10.1007/BF00280059

Cite this article as:
Jacqz-Aigrain, E., Wood, C. & Robieux, I. Eur J Clin Pharmacol (1990) 39: 191. doi:10.1007/BF00280059

Summary

Midazolam is a water soluble benzodiazepine, with a short elimination half-life in adults and children. An IV bolus of midazolam 0.2 mg · kg−1 was administered to 10 critically ill neonates receiving intensive care who required sedation.

The plasma clearance was 6.85 ml · min−1 and the elimination half-life was 6.52 h. Midazolam was well tolerated during and after administration.

Because of its short half-life compared to diazepam, midazolam could be used during the neonatal period to produce brief rapid sedation.

Key words

MidazolamNeonatesPharmacokineticsSedation

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • E. Jacqz-Aigrain
    • 1
  • C. Wood
    • 2
  • I. Robieux
    • 1
  1. 1.Unité de Pharmacologie Clinique Hôpital Robert DebreParisFrance
  2. 2.Service de Reanimation Pediatrique Hôpital BicêtreParisFrance