European Journal of Clinical Pharmacology

, Volume 39, Issue 2, pp 173–176

Variation of benzbromarone elimination in man — a population study

Authors

  • I. Walter-Sack
    • Abteilung Klinische Pharmakologie der Medizinischen KlinikUniversität Heidelberg
  • U. Gresser
    • Medizinische PoliklinikLudwig-Maximilians-Universität
  • M. Adjan
    • Medizinische PoliklinikLudwig-Maximilians-Universität
  • I. Kamilli
    • Medizinische PoliklinikLudwig-Maximilians-Universität
  • A. Ittensohn
    • Abteilung Klinische Pharmakologie der Medizinischen KlinikUniversität Heidelberg
  • J. X. de Vries
    • Abteilung Klinische Pharmakologie der Medizinischen KlinikUniversität Heidelberg
  • E. Weber
    • Abteilung Klinische Pharmakologie der Medizinischen KlinikUniversität Heidelberg
  • N. Zöllner
    • Medizinische PoliklinikLudwig-Maximilians-Universität
Originals

DOI: 10.1007/BF00280054

Cite this article as:
Walter-Sack, I., Gresser, U., Adjan, M. et al. Eur J Clin Pharmacol (1990) 39: 173. doi:10.1007/BF00280054

Summary

The plasma benzbromarone concentration-time profile in a healthy subject who retained the compound much longer than other individuals is described. The data suggested that determination of the 24 h plasma concentration of the parent drug after a single oral dose of 100 mg benzbromarone would be an appropriate procedure to determine the elimination phenotype. Based on this procedure, 148 of 153 healthy individuals (97%) in a population study were found to eliminate benzbromarone rapidly. In one subject the 24 h benzbromarone plasma concentration was very similar to the that observed in the individual who had been more fully characterized. Four participants gave intermediate results. The data are compatible with a bimodal or trimodal distribution of different benzbromarone elimination phenotypes.

Key words

Benzbromaroneeliminationphenotype distributiondrug metabolismdrug polymorphismadverse reaction

Copyright information

© Springer-Verlag 1990