Diabetologia

, Volume 30, Issue 7, pp 464–467

Peripheral nerve concentrations of glucose, fructose, sorbitol and myoinositol in diabetic and non-diabetic patients

  • P. J. Hale
  • M. Nattrass
  • S. H. Silverman
  • C. Sennit
  • C. M. Perkins
  • A. Uden
  • G. Sundkvist
Originals

DOI: 10.1007/BF00279613

Cite this article as:
Hale, P.J., Nattrass, M., Silverman, S.H. et al. Diabetologia (1987) 30: 464. doi:10.1007/BF00279613

Summary

Glucose, fructose, sorbitol and myoinositol concentrations were measured in biopsies of peripheral nerve obtained at above-knee or below-knee amputation. In diabetic patients nerve glucose (median [range]) (5.09 [1.62–12.82] vs 3.12 [1.81–4.01]) p<0.001, fructose (0.245 [0.060–1.280] vs 0.150 [0.053–0.385]) p<0.05, and sorbitol (0.028 [0.012–0.496] vs 0.016 [0.007–0.059] p<0.02, μmol/g wet weight) were significantly higher than in non-diabetic patients. No significant difference was found in myoinositol concentration (1.95 [1.00–3.55] vs 2.09 [1.27–5.40] μmol/g wet weight). Concentrations differed markedly from previously reported values in human nerve obtained at post-mortem.

Key words

Nerve glucosefructosesorbitolmyoinositol

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • P. J. Hale
    • 1
  • M. Nattrass
    • 1
  • S. H. Silverman
    • 1
  • C. Sennit
    • 2
  • C. M. Perkins
    • 2
  • A. Uden
    • 3
  • G. Sundkvist
    • 4
  1. 1.Diabetic ClinicGeneral HospitalBirmingham
  2. 2.ICI PharmaceuticalsMacclesfieldUK
  3. 3.Department of OrthopaedicsUniversity of Lund, Malmo General HospitalMalmoSweden
  4. 4.Department of MedicineUniversity of Lund, Malmo General HospitalMalmoSweden