No effect of cisapride on paracetamol absorption after oral simultaneous administration
Received: 20 April 1991 Accepted: 15 August 1991 DOI:
Cite this article as: Rowbotham, D.J., Parnacott, S. & Nimmo, W.S. Eur J Clin Pharmacol (1992) 42: 235. doi:10.1007/BF00278493 Summary
We have measured the effect of oral cisapride on paracetamol absorption in 12 healthy volunteers in a double-blind placebo-controlled study. Volunteers received paracetamol plus placebo, paracetamol plus cisapride 10 mg and paracetamol plus cisapride 20 mg.
Mean plasma paracetamol AUC at 60 min were 1070, 1051 and 1031 μg·min·ml
−1 and maximum paracetamol concentrations were 31.5, 29.3 and 27.4 μg·ml −1 respectively (no significant differences).
There was no difference also in time to maximum paracetamol concentration [median (range) 30 (15–120), 30 (15–90) and 30 (15–60) min, respectively].
Key words Cisapride Paracetamol absorption gastric emptying healthy volunteers References
Baeyens R, Reyntjens A, Verlinden M (1984) Cisapride accelerates gastric emptying and mouth-to-caecum transit of a barium meal. Eur J Clin Pharmacol 27: 315–318
Bricker SRW, McLuckie A, Nightingale DA (1989) Gastric aspirates after trauma in children. Anaesth 44: 721–724
Crome P, Kimber GR, Wainscott G, Widdop B (1981) The effect of the simultaneous administration of oral metoclopramide on the absorption of paracetamol in healthy volunteers. Br J Clin Pharmacol 11: 430P-431P
Dougall JR, Cunningham B, Nimmo WS (1983) Paracetamol absorption from paramax, panadol and solpadeine. Br J Clin Pharmacol 15: 487–489
Heading RC, Nimmo J, Prescott LF, Tothill P (1973) The dependence of paracetamol absorption on the rate of gastric emptying. Br J Pharmacol 47: 415–421
Howie D, Adriaenssens PI, Prescott LF (1977) Paracetamol metabolism following overdosage: Application of high performance liquid chromatography. J Pharm Pharmacol 29: 235–237
Kreel L (1973) The use of metoclopramide in radiology. Postgrad Med J 49 [Suppl 4]: 42–45
Manara AR, Quinn KG, Park GR (1990) Oral metoclopramide does not speed the absorption of concurrently administered paracetamol. Eur J Anaesth 7: 1–7
McCallum RW, Chakrapani P, Campoli-Richards DM, Goa KL (1988) Cisapride. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use as a prokinetic agent in gastrointestinal motility disorders. Drugs 36: 652–681