Histochemie

, Volume 25, Issue 4, pp 289–296

Peroxidase-dependent oxidation of tyrosine or dopa to melanin in neurons

  • Milton R. Okun
  • Barbara Donnellan
  • Walter F. Lever
  • Leon M. Edelstein
  • Nur Or
Article

DOI: 10.1007/BF00278222

Cite this article as:
Okun, M.R., Donnellan, B., Lever, W.F. et al. Histochemie (1971) 25: 289. doi:10.1007/BF00278222

Summary

Peroxidase activity was demonstrated in guinea pig frontal lobe by histochemical methods, and was correlated with peroxidase-dependent enzymatic synthesis of melanin from tyrosine or dopa. Peroxidase activity and peroxidase-dependent melanin synthesis appeared to be mainly in lysosomes of neurons. These findings open the possibility that peroxidase may have a role in catecholamine, lipofuscin and neuromelanin synthesis in the brain.

Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • Milton R. Okun
    • 1
  • Barbara Donnellan
    • 1
  • Walter F. Lever
    • 1
  • Leon M. Edelstein
    • 2
  • Nur Or
    • 2
  1. 1.Department of DermatologyTufts University School of MedicineBoston
  2. 2.Department of PathologySt. Vincent HospitalWorcester

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