Peroxidase-dependent oxidation of tyrosine or dopa to melanin in neurons
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- Okun, M.R., Donnellan, B., Lever, W.F. et al. Histochemie (1971) 25: 289. doi:10.1007/BF00278222
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Peroxidase activity was demonstrated in guinea pig frontal lobe by histochemical methods, and was correlated with peroxidase-dependent enzymatic synthesis of melanin from tyrosine or dopa. Peroxidase activity and peroxidase-dependent melanin synthesis appeared to be mainly in lysosomes of neurons. These findings open the possibility that peroxidase may have a role in catecholamine, lipofuscin and neuromelanin synthesis in the brain.