Diabetologia

, Volume 31, Issue 11, pp 831–835

Urinary excretion of 1,5-anhydro-D-glucitol accompanying glucose excretion in diabetic patients

Authors

  • Y. Akanuma
    • Institute for Diabetes Care and ResearchAsahi Life Foundation
  • M. Morita
    • Department of Chemistry, College of Arts and SciencesUniversity of Tokyo
  • N. Fukuzawa
    • Institute for Diabetes Care and ResearchAsahi Life Foundation
  • T. Yamanouchi
    • The Second Department of Internal MedicineUniversity of Teikyo
  • H. Akanuma
    • Department of Chemistry, College of Arts and SciencesUniversity of Tokyo
Originals

DOI: 10.1007/BF00277486

Cite this article as:
Akanuma, Y., Morita, M., Fukuzawa, N. et al. Diabetologia (1988) 31: 831. doi:10.1007/BF00277486

Summary

The urinary excretion of 1,5-anhydro-D-glucitol, a pyranoid polyol, in humans was studied. The plasma of nondiabetic human subjects contained high concentrations of this polyol (>110 μmol/l), and there was a tendency for the 24-h excretion of it to become more variable in direct proportion to its plasma concentration. In contrast, diabetic patients showed lower plasma concentrations of this polyol, and the variation in the 24-h excretion of 1,5-anhydro-D-glucitol was especially notable among the patients with an extremely low plasma concentration of the polyol. This diabetic group showed a statistically significant correlation (p<0.01), between the urinary 1,5-anhydro-D-glucitol and urinary glucose. This correlation was more markedly demonstrated during a 100-g oral glucose tolerance test: parallel changes were observed in the concentrations of 1,5-anhydro-D-glucitol and glucose in the urine collected every hour after the glucose load. These observations led to the proposal that low plasma concentration of this polyol, which is observed in diabetes mellitus, may be the result of a frequent and/or prolonged high blood glucose concentration beyond the renal threshold for glucose excretion.

Key words

1,5-anhydroglucitolurinary excretionreabsorptionglucosuriahyperglycaemia

Copyright information

© Springer-Verlag 1988