Human Genetics

, Volume 85, Issue 1, pp 80–84

Inv(14) with distal breakpoint in 14q32.1 in three cases of T cell lymphoma

  • Brigitte Schlegelberger
  • Alfred C. Feller
  • Hans-Heinrich Wacker
  • Jürgen Lohmeyer
  • Werner Grote
Original Investigations

DOI: 10.1007/BF00276328

Cite this article as:
Schlegelberger, B., Feller, A.C., Wacker, H. et al. Hum Genet (1990) 85: 80. doi:10.1007/BF00276328

Summary

The distal breakpoint of inv(14) in T cell clones, established from patients with ataxia telangiectasia, lies outside the immunoglobulin heavy chain gene locus on 14q32.3, and more proximal to the centromere than the distal breakpoint of inv(14) in the T cell lymphoma cell line SUP-T1. We report 3 cases of T cell lymphoma cytogenetically showing the same type of inv(14) as the AT T cell clones. All 3 cases express a similar immunophenotype, which is that of peripheral T lymphocytes with phenotypic remnants of thymic or postthymic lymphoblasts. This finding provides evidence that this type of inv(14) is involved in the malignant transformation of mature T lymphocytes.

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Brigitte Schlegelberger
    • 1
  • Alfred C. Feller
    • 2
  • Hans-Heinrich Wacker
    • 3
  • Jürgen Lohmeyer
    • 4
  • Werner Grote
    • 1
  1. 1.Abteilung Humangenetik, Zentrum Konservative Medizin II der Christian Albrechts-UniversitätKielFederal Republic of Germany
  2. 2.Pathologisches Institut der UniversitätWürzburgFederal Republic of Germany
  3. 3.Abteilung Allgemeine Pathologie und pathologische Anatomie, Zentrum Klinisch-Theoretische Medizin I der Christian Albrechts-UniversitätKielFederal Republic of Germany
  4. 4.Abteilung Hämatologie, Zentrum für Innere Medizin der UniversitätGiessenFederal Republic of Germany