Complete moles have paternal chromosomes but maternal mitochondrial DNA
- Cite this article as:
- Wallace, D.C., Surti, U., Adams, C.W. et al. Hum Genet (1982) 61: 145. doi:10.1007/BF00274205
Complete hydatidiform moles contain only paternal chromosomes. To learn more of their origin, we used restriction endonuclease site polymorphisms found in the parental mitochondrial DNAs to demonstrate that moles contain exclusively maternal mitochondrial DNA. Thus, moles must arise from the fusion of one or two sperm with a mature but anucleate ovum.