Molecular and General Genetics MGG

, Volume 155, Issue 3, pp 279–286

The dependence of postreplication repair on uvrB in a recF mutant of Escherichia coli K-12

  • Robert H. Rothman
  • Alvin J. Clark

DOI: 10.1007/BF00272806

Cite this article as:
Rothman, R.H. & Clark, A.J. Molec. Gen. Genet. (1977) 155: 279. doi:10.1007/BF00272806


Mutants carrying recF143 or recF144 show wild type levels of host cell reactivation of UV-irradiated λvir and wild type rates of excision gap closure in repairing UV damage to their own DNA. The same mutants showed reduced rates of postreplication repair strand joining. When uvrA- recF- or uvrB- recF- strains are tested, postreplication repair strand joining is incomplete or does not occur at fluences above 1 J/m2. We suggest that there may be a UvrAB and a RecF pathway of postreplication repair or that the repair functions controlled or determined by uvrA uvrB and by recF may be similar. An intermediate in postreplication repair may accumulate in the uvr- recF- strain.

Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • Robert H. Rothman
    • 1
  • Alvin J. Clark
    • 2
  1. 1.Department of GeneticsUniversity of CaliforniaBerkeleyUSA
  2. 2.Department of Molecular BiologyUniversity of CaliforniaBerkeleyUSA
  3. 3.Department of BiologyBrookhaven National LaboratoryUpton, L.I.