Molecular and General Genetics MGG

, Volume 165, Issue 1, pp 87–93

Uvm mutants of Escherichia coli K 12 deficient in UV mutagenesis

I. Isolation of uvm mutants and their phenotypical characterization in DNA repair and mutagenesis
  • Gerhard Steinborn
Article

DOI: 10.1007/BF00270380

Cite this article as:
Steinborn, G. Molec. Gen. Genet. (1978) 165: 87. doi:10.1007/BF00270380

Summary

Selection for defective reversion induction, after UV treatment of E. coli K 12, yielded uvm mutants. These mutants exhibited highly reduced or no UV mutability for all loci tested although they were moderately and normally mutable by X-rays and EMS, respectively. Uvm mutations confer only a slight sensitivity to killing by UV and X-rays and no clear sensitivity to the lethal effect of HN2, EMS or MMS. Growth and viability of untreated uvm cells were normal. The properties of uvm mutants are discussed in relation to those of other relevant mutant types and to some actual problems of induced mutagenesis.

Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Gerhard Steinborn
    • 1
  1. 1.Zentralinstitut für Genetik und Kulturpflanzenforschung der ADW der DDRGaterslebenGerman Democratic Republic

Personalised recommendations