Molecular and General Genetics MGG

, Volume 160, Issue 2, pp 195–202

Virulent mutants of temperate phage Mu-1

Authors

  • Françoise van Vliet
    • Department de Biologie MoléculaireUniversité Libre de Bruxelles
  • Martine Couturier
    • Department de Biologie MoléculaireUniversité Libre de Bruxelles
  • Lucie Desmet
    • Department de Biologie MoléculaireUniversité Libre de Bruxelles
  • Michel Faelen
    • Department de Biologie MoléculaireUniversité Libre de Bruxelles
  • Ariane Toussaint
    • Department de Biologie MoléculaireUniversité Libre de Bruxelles
Article

DOI: 10.1007/BF00267481

Cite this article as:
van Vliet, F., Couturier, M., Desmet, L. et al. Molec. Gen. Genet. (1978) 160: 195. doi:10.1007/BF00267481

Summary

Virulent mutants of phage Mu have been isolated after mutagenesis. The virulent phenotype results from most probably 2 mutations located in the c-A region of the Mu genome.

Vir mutants are trans-dominant; they induce the resident prophage upon infection in broth of any Mu lysogen. They however form plaques only on certain lysogens, that are monolysogenic for a mutant prophage. We further isolated secondary mutations in Mu Vir which suppress the virulent phenotype.

Copyright information

© Springer-Verlag 1978