Applied Microbiology and Biotechnology

, Volume 29, Issue 4, pp 323–328

Model for continuous production of solvents from whey permeate in a packed bed reactor using cells of Clostridium acetobutylicum immobilized by adsorption onto bonechar


  • N. Qureshi
    • Biotechnology DepartmentMassey University
  • A. H. J. Paterson
    • Biotechnology DepartmentMassey University
  • I. S. Maddox
    • Biotechnology DepartmentMassey University

DOI: 10.1007/BF00265814

Cite this article as:
Qureshi, N., Paterson, A.H.J. & Maddox, I.S. Appl Microbiol Biotechnol (1988) 29: 323. doi:10.1007/BF00265814


A mathematical model has been developed to describe the operation of a packed bed reactor for the continuous production of solvents from whey permeate. The model has been used to quantitate the amounts of different physiological/ morphological types of biomass present in the reactor. The majority of biomass is inert, i.e. it neither grows nor produces solvent. Only relatively small amounts of biomass actively grow (vegetative, non-solvent-producing cells), while even smaller amounts are responsible for solvent production (clostridial, solvent-producing cells).

Copyright information

© Springer-Verlag 1988