European Biophysics Journal

, Volume 12, Issue 2, pp 115–119

The tRNA cycle and its relation to the rate of protein synthesis

  • H. Liljenström
  • G. von Heijne
  • C. Blomberg
  • J. Johansson
Article

DOI: 10.1007/BF00260434

Cite this article as:
Liljenström, H., von Heijne, G., Blomberg, C. et al. Eur Biophys J (1985) 12: 115. doi:10.1007/BF00260434

Abstract

With the aid of a kinetic model, we have investigated how the adaptation between the various components of the tRNA cycle and the codon frequencies affects the rate of protein synthesis. Depending on the relative amounts of total tRNA, synthetase and ribosomes, the optimal correlations vary between a situation where all tRNA species are either present in equal amounts or are present in amounts proportional to the square-root of the corresponding codon frequencies, and a situation where the amounts of the different tRNA species present are linearly proportional to the codon frequencies.

Key words

tRNA cycle optimization elongation rate codon frequency tRNA synthetase 

Abbreviations

EFTu

Elongation factor Tu

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • H. Liljenström
    • 1
  • G. von Heijne
    • 1
  • C. Blomberg
    • 1
  • J. Johansson
    • 1
  1. 1.Research Group for Theoretical Biophysics, Department of Theoretical PhysicsRoyal Institute of TechnologyStockholmSweden