Cancer Chemotherapy and Pharmacology

, Volume 14, Issue 3, pp 247–249

Beta-2-microglobulin excretion: An indicator of long term nephrotoxicity during cis-platinum treatment?

Authors

  • Peter Grundtvig Sørensen
    • Department of Clinical PhysiologyThe Finsen Institute
    • Department of Clinical ChemistryThe Finsen Institute
    • Department of Chemotherapy R II-VThe Finsen Institute
  • Mogens H. Nissen
    • Department of Clinical PhysiologyThe Finsen Institute
    • Department of Clinical ChemistryThe Finsen Institute
    • Department of Chemotherapy R II-VThe Finsen Institute
  • Steffen Groth
    • Department of Clinical PhysiologyThe Finsen Institute
    • Department of Clinical ChemistryThe Finsen Institute
    • Department of Chemotherapy R II-VThe Finsen Institute
  • Mikael Rørth
    • Department of Clinical PhysiologyThe Finsen Institute
    • Department of Clinical ChemistryThe Finsen Institute
    • Department of Chemotherapy R II-VThe Finsen Institute
Original Articles Beta-2-microglobulin and cis-platinum

DOI: 10.1007/BF00258126

Cite this article as:
Sørensen, P.G., Nissen, M.H., Groth, S. et al. Cancer Chemother. Pharmacol. (1985) 14: 247. doi:10.1007/BF00258126

Summary

To evaluate the value of beta-2-microglobulin as an indicator of acute and long-term cis-platinum-induced nephrotoxicity, 51Cr-EDTA clearance and serum concentration and urinary excretion of beta-2-microglobulin were measured in 18 patients treated with a regimen, including cis-platinum. Before treatment all values were within the normal range. During treatment 51Cr-EDTA clearance decreased from 108 to 90 ml/min/1.73 m2 (P<0.02). The decrease was irreversible, while a transient 2 to 5-fold increase in beta-2-microglobulin excretion in the urine was seen during treatment. Serum beta-2-microglobulin remained unchanged. The decrease in 51Cr-EDTA clearance was not correlated to either the peak increase in the beta-2-microglobulin excretion or to the time of occurrence of the peak (R=0.3). Thus, it is not possible to predict the long-term nephrotoxicity of cis-platinum by measuring the beta-2-microglobulin excretion during treatment.

Copyright information

© Springer-Verlag 1985