Originals

Diabetologia

, Volume 20, Issue 1, pp 45-46

Buformin concentrations in a case of fatal lactic acidosis

  • L. F. VerdonckAffiliated withDepartments of Internal Medicine, University Hospital
  • , B. SangsterAffiliated withDepartments of Reanimation and Clinical Toxicology, University HospitalNational Poison Control Centre, National Institute of Public Health
  • , A. N. P. van HeijstAffiliated withDepartments of Reanimation and Clinical Toxicology, University HospitalNational Poison Control Centre, National Institute of Public Health
  • , G. de GrootAffiliated withCentre for Human Toxicology, State University
  • , R. A. A. MaesAffiliated withCentre for Human Toxicology, State University

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Summary

A fatal case of lactic acidosis in a 84 year old diabetic woman taking buformin is reported. Buformin concentrations in serum, other body fluids and tissues were measured by gas chromatography. Serum buformin concentration at admission was 5.5 mg/1. Postmortem concentrations were: in serum 3.2mg/l; in lung 2.8mg/kg wet weight; in heart 3.0mg/kg; in pericardial fluid 3.5 mg/1; in liver 5.2 mg/kg; in bile 6.3 mg/1; and in kidney 98 mg/kg.

Key words

Lactic acidosis plasma buformin concentration tissue buformin concentration biguanides