Diabetologia

, Volume 20, Issue 1, pp 45–46

Buformin concentrations in a case of fatal lactic acidosis

Authors

  • L. F. Verdonck
    • Departments of Internal MedicineUniversity Hospital
  • B. Sangster
    • Departments of Reanimation and Clinical ToxicologyUniversity Hospital
    • National Poison Control CentreNational Institute of Public Health
  • A. N. P. van Heijst
    • Departments of Reanimation and Clinical ToxicologyUniversity Hospital
    • National Poison Control CentreNational Institute of Public Health
  • G. de Groot
    • Centre for Human ToxicologyState University
  • R. A. A. Maes
    • Centre for Human ToxicologyState University
Originals

DOI: 10.1007/BF00253815

Cite this article as:
Verdonck, L.F., Sangster, B., van Heijst, A.N.P. et al. Diabetologia (1981) 20: 45. doi:10.1007/BF00253815

Summary

A fatal case of lactic acidosis in a 84 year old diabetic woman taking buformin is reported. Buformin concentrations in serum, other body fluids and tissues were measured by gas chromatography. Serum buformin concentration at admission was 5.5 mg/1. Postmortem concentrations were: in serum 3.2mg/l; in lung 2.8mg/kg wet weight; in heart 3.0mg/kg; in pericardial fluid 3.5 mg/1; in liver 5.2 mg/kg; in bile 6.3 mg/1; and in kidney 98 mg/kg.

Key words

Lactic acidosisplasma buformin concentrationtissue buformin concentrationbiguanides

Copyright information

© Springer-Verlag 1981