Buformin concentrations in a case of fatal lactic acidosis
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- Verdonck, L.F., Sangster, B., van Heijst, A.N.P. et al. Diabetologia (1981) 20: 45. doi:10.1007/BF00253815
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A fatal case of lactic acidosis in a 84 year old diabetic woman taking buformin is reported. Buformin concentrations in serum, other body fluids and tissues were measured by gas chromatography. Serum buformin concentration at admission was 5.5 mg/1. Postmortem concentrations were: in serum 3.2mg/l; in lung 2.8mg/kg wet weight; in heart 3.0mg/kg; in pericardial fluid 3.5 mg/1; in liver 5.2 mg/kg; in bile 6.3 mg/1; and in kidney 98 mg/kg.