Applied Microbiology and Biotechnology

, Volume 22, Issue 6, pp 424–427

Use of controlled-release polymer to feed ammonium to Streptomyces clavuligerus cephalosporin fermentations in shake flasks

  • C. Lübbe
  • A. L. Demain
  • K. Bergman
Rapid Communication

DOI: 10.1007/BF00252784

Cite this article as:
Lübbe, C., Demain, A.L. & Bergman, K. Appl Microbiol Biotechnol (1985) 22: 424. doi:10.1007/BF00252784

Summary

Controlled-release polymers containing NH4Cl were used to feed NH4+to Streptomyces clavuligerus cultures making cephalosporins in shake flasks. Production was improved in comparison to free NH4Cl included in the medium at various concentrations; it approached the performance of l-asparagine, the best single nitrogen source for production.

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • C. Lübbe
    • 1
  • A. L. Demain
    • 1
  • K. Bergman
    • 1
  1. 1.Fermentation Microbiology Laboratory, Department of Applied Biological SciencesMassachusetts Institute of TechnologyCambridgeUSA
  2. 2.Fermentation Process DevelopmentPharmaceutical Research DivisionUnionUSA
  3. 3.Department of BiologyNortheastern UniversityBostonUSA