Use of controlled-release polymer to feed ammonium to Streptomyces clavuligerus cephalosporin fermentations in shake flasks
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- Lübbe, C., Demain, A.L. & Bergman, K. Appl Microbiol Biotechnol (1985) 22: 424. doi:10.1007/BF00252784
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Controlled-release polymers containing NH4Cl were used to feed NH4+to Streptomyces clavuligerus cultures making cephalosporins in shake flasks. Production was improved in comparison to free NH4Cl included in the medium at various concentrations; it approached the performance of l-asparagine, the best single nitrogen source for production.