, Volume 20, Issue 5, pp 530–534

Effect of strict blood glucose control on residual B-cell function in insulin-dependent diabetics


  • S. Madsbad
    • Hvidøre Hospital
  • T. Krarup
    • Hvidøre Hospital
  • L. Regeur
    • Hvidøre Hospital
  • O. K. Faber
    • Hvidøre Hospital
  • C. Binder
    • Hvidøre Hospital

DOI: 10.1007/BF00252760

Cite this article as:
Madsbad, S., Krarup, T., Regeur, L. et al. Diabetologia (1981) 20: 530. doi:10.1007/BF00252760


In 14 insulin dependent diabetics past their initial remission period B-cell function was evaluated using a test meal before and after 1 week of strict blood glucose control, and again 3 weeks later when the patients were outpatients on conventional therapy. Eight patients with fasting C-peptide above 0.07 nmol/l improved their B-cell function significantly (p<0.05) during the period of strict blood glucose control. However, the improvement was of short duration and was absent 3 weeks later in most patients. Six patients with fasting C-peptide below or equal to 0.07 nmol/l had no significant improvement in B-cell function during the period of strict control. The study shows that B-cell function and degree of blood glucose control are related in patients with fasting C-peptide above 0.07 nmol/l, and that B-cell function can change within days.

Key words

Glycaemic controlB-cell functioninsulin-dependent diabeticsC-peptideendogenous insulin secretion

Copyright information

© Springer-Verlag 1981