Experimental Brain Research

, Volume 11, Issue 4, pp 376–386

Perseverative interference in monkeys following selective lesions of the inferior prefrontal convexity


  • Susan D. Iversen
    • Psychological Laboratory University of Cambridge
  • Mortimer Mishkin
    • Dept. of Health Education and WelfareNational Institute of Mental Health

DOI: 10.1007/BF00237911

Cite this article as:
Iversen, S.D. & Mishkin, M. Exp Brain Res (1970) 11: 376. doi:10.1007/BF00237911


Monkeys with lesions of the inferior frontal convexity were impaired relative to controls in retaining an auditory frequency differentiation (although subsequent thresholds were normal) and in learning object and spatial reversals. Performance was characterized by perseverative interference, a frontal symptom which now seems attributable to damage to the inferior convexity.

Key Words

Prefrontal cortexAblationSupramodal deficitPerseverative interference

Copyright information

© Springer-Verlag 1970