Cell and Tissue Research

, Volume 215, Issue 1, pp 133–142

Hepatocyte differentiation during early fetal development in the rat

  • Annarosa Ciofi Luzzatto

DOI: 10.1007/BF00236254

Cite this article as:
Luzzatto, A.C. Cell Tissue Res. (1981) 215: 133. doi:10.1007/BF00236254


Rat hepatocyte differentiation between day 12 and 19 of fetal life was studied by electron microscopy. The cytoplasmic structures involved in synthetic and secretory function, i.e., rough endoplasmic reticulum and Golgi apparatus, appear to be the first to differentiate, and their development is probably related to the secretion of different kinds of plasma proteins. The cytoplasmic organelles involved in other hepatic functions develop later: lysosomes from day 15, peroxysomes, glycogen rosettes and smooth endoplasmic reticulum still later. However, the morphological differentiation of bile canaliculi begins from day 12.

Key Words

Rat fetusHepatocyte differentiationUltrastructureElectron microscopy

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • Annarosa Ciofi Luzzatto
    • 1
  1. 1.Istituto di Istologia ed Embriologia, Facoltà di ScienzeM.F.N. Università di RomaRomeItaly
  2. 2.Istituto di Istologia ed Embriologia, Facoltà di ScienzeM.F.N., Università di Roma, Città UniversitariaRomeItaly