Experimental Brain Research

, Volume 54, Issue 2, pp 382–384

Effects of motor cortex stimulation on spinal interneurones in intact man

  • J. C. Rothwell
  • B. L. Day
  • A. Berardelli
  • C. D. Marsden
Research Note

DOI: 10.1007/BF00236241

Cite this article as:
Rothwell, J.C., Day, B.L., Berardelli, A. et al. Exp Brain Res (1984) 54: 382. doi:10.1007/BF00236241
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Summary

The effect of a descending corticospinal volley on a spinal inhibitory pathway, has been studied in five intact human subjects. Approximately 63% inhibition of the H-reflex evoked in wrist and finger flexor muscles, was produced by motor threshold stimulation of the radial nerve. When a submotor threshold cortical shock was given 2 to 4 ms before the H-reflex, this inhibition was reduced to approximately 38%. The timing of this effect is compatible with either a monosynaptic or disynaptic corticospinal tract projection onto the spinal inhibitory interneurone.

Key words

Cortical stimulation Ia inhibition H-reflex Spinal cord Human 

Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • J. C. Rothwell
    • 1
  • B. L. Day
    • 1
  • A. Berardelli
    • 1
  • C. D. Marsden
    • 1
  1. 1.Department of NeurologyInstitute of Psychiatry and King's College Hospital Medical SchoolDenmark Hill, LondonEngland
  2. 2.V. Clinica Neurologica, Dipartimento di Scienze NeurologicheUniversita di Roma “La Sapienza”RomaItaly

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