Molecular and Cellular Biochemistry

, Volume 106, Issue 2, pp 161–170

Characterization of new members of the pregnancy-specific β1-glycoprotein family

  • Wai-Yee Chan
  • Qiao-Xi Zheng
  • Julie McMahon
  • Le Ann Teasel
Article

DOI: 10.1007/BF00230182

Cite this article as:
Chan, WY., Zheng, QX., McMahon, J. et al. Mol Cell Biochem (1991) 106: 161. doi:10.1007/BF00230182

Abstract

Three cDNAs encoding members of the pregnancy-specific β1-glycoprotein (PSG) family were isolated from human term placental cDNA library. All three cDNAs encode proteins with similar domain structure. There is a leader sequence of 34 amino acids followed by an N-domain of 109 amino acids. Immediately after the N-domain are one or two copies of a repeating A-domain of 93 amino acids, a B-domain of 85 amino acids and a C-domain of variable size. The proteins are highly hydrophilic. However, one of them has an 81-amino acid C-domain which is very hydrophobic and could potentially serve as a membrane attachment site. The putative cell-cell recognition tripeptide, Arg-Gly-Asp, is present in the N-domain of two of the proteins. Partial sequence of one of the cDNAs has been found in HeLa cells while cDNAs highly homologous to two of the cDNAs have been found in the fetal liver. Functional roles of the PSG proteins basing on their structure are proposed.

Key words

cDNA human placenta immunoglobulin pregnancy-specific β1-glycoprotein 

Abbreviations

PSG

Pregnancy-Specific β1-Glycoprotein, according to nomenclature recommended at the ISOBM XVII Meeting, 1989 [31]

CEA

Carcinoembryonic Antigen

bp

base-pair

kb

kilo-base-pair

nt

nucleotide

aa

amino acid

UTR

Untranslated Region

RGD

Arg-Gly-Asp

Copyright information

© Kluwer Academic Publishers 1991

Authors and Affiliations

  • Wai-Yee Chan
    • 1
    • 2
  • Qiao-Xi Zheng
    • 1
  • Julie McMahon
    • 1
  • Le Ann Teasel
    • 1
  1. 1.Departments of PediatricsGeorgetown University Medical CenterWashington, DCUSA
  2. 2.Departments of Biochemistry & Molecular Biology, and Anatomy & Cell BiologyGeorgetown University Medical CenterWashington, DCUSA

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