Experimental Brain Research

, Volume 110, Issue 3, pp 367–378

A light- and electron-microscopic study of GluR4-positive cells in cerebral cortex, subcortical white matter and corpus callosum of neonatal, immature and adult rats

Authors

  • W. Y. Ong
    • Department of AnatomyNational University of Singapore
  • S. K. Leong
    • Department of AnatomyNational University of Singapore
  • L. J. Garey
    • Department of AnatomyCharing Cross and Westminster Medical School
  • R. Reynolds
    • Department of AnatomyCharing Cross and Westminster Medical School
Research Article

DOI: 10.1007/BF00229137

Cite this article as:
Ong, W.Y., Leong, S.K., Garey, L.J. et al. Exp Brain Res (1996) 110: 367. doi:10.1007/BF00229137

Abstract

The distribution of the [3H]alpha-amino-3-hydroxy-5-methylisoxzalepropionic acid (AMPA) receptor subunit GluR4 was studied in frontal, parietal and temporal cerebral cortex, subcortical white matter and corpus callosum of neonatal, immature and mature rats. In 1-to 2-day-old rats, a few oligodendrocyte progenitors and amoeboid microglia in the supraventricular part of the corpus callosum were immunolabelled for GluR4. At 7 to 10 days, the number of amoeboid microglia and oligodendrocyte progenitors in white matter increased; many neurons in cortex, including pyramidal neurons, were also moderately labelled for GluR4. The pattern of GluR4 immunostaining in 14-day-old rats was different from that in 7-to 10-day-old rats, but similar to the adult, in that there was no immunoreactivity in microglia and oligodendrocyte progenitors in subcortical white matter. A proportion of non-pyramidal neurons in cortex were moderately labelled, while some pyramidal neurons were lightly labelled. A population of small glial cells with features of oligodendrocyte progenitors were densely labelled in cortex.

Key words

Glutamate receptorCerebral cortexWhite matterElectron microscopyDevelopmentRat
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Copyright information

© Springer-Verlag 1996