Cell and Tissue Research

, Volume 235, Issue 3, pp 551–559

Connective tissue influences on patterns of epithelial architecture and keratinization in skin and oral mucosa of the adult mouse

  • Ian C. Mackenzie
  • Murray W. Hill

DOI: 10.1007/BF00226952

Cite this article as:
Mackenzie, I.C. & Hill, M.W. Cell Tissue Res. (1984) 235: 551. doi:10.1007/BF00226952


Epithelial-mesenchymal interactions play an important role during embryogenesis but it is uncertain whether such interactions influence the maintenance of epithelial structure in the adult. To examine this problem, separated epithelial and connective tissue components of skin and mucosae from various regions of adult mice were homoor heterotypically recombined and transplanted to histocompatible hosts. The patterns of tissue architecture and keratinization of the resultant epithelia were examined for changes indicative of mesenchymal influences on the epithelial phenotype. Each type of epithelium, in some recombinations, fully conserved its normal pattern of phenotypic expression indicating that subepithelial connective tissue from all regions is permissive and that regionally-specific connective tissue influences are not necessary for conservation of epithelial specificity. In other recombinations, however, the epithelium acquired features of tissue architecture or keratinization typical of the epithelium normally associated with the connective tissue component, indicating directive influ ences from the connective tissue. The patterns of epithelial response observed suggest that there may be separate connective tissue influences on epithelial architecture and cytodifferentiation and that there is a regionally-related variation in the competence of epithelia to respond to these influences.

Key words

Epithelial-mesenchymal interactions Skin Oral mucosa 

Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • Ian C. Mackenzie
    • 1
  • Murray W. Hill
    • 1
  1. 1.Dows Institute for Dental Research, College of DentistryThe University of IowaIowa CityUSA
  2. 2.Dows Institute for Dental Research, College of DentistryThe University of IowaIowa CityUSA

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