Human Genetics

, Volume 95, Issue 3, pp 265–269

Chromosomal localization of the human NF-E2 family of bZIP transcription factors by fluorescence in situ hybridization

Authors

  • Jefferson Y. Chan
    • Department of Laboratory MedicineUniversity of California
  • Mei-Chi Cheung
    • Howard Hughes Medical Institute at the University of California
  • Paolo Moi
    • Istituto di Clinica e Biologia dell' Eta EvolutivaUniversita di Cagliari
  • Kaiman Chan
    • Howard Hughes Medical Institute at the University of California
  • Yuet Wai Kan
    • Department of Laboratory MedicineUniversity of California
    • Howard Hughes Medical Institute at the University of California
Original Investigation

DOI: 10.1007/BF00225191

Cite this article as:
Chan, J.Y., Cheung, M., Moi, P. et al. Hum Genet (1995) 95: 265. doi:10.1007/BF00225191

Abstract

A family of human genes encoding basic-leucine zipper (bZIP) transcription factors, p45-NF-E2, Nrf1 and Nrf2, have been isolated independently. Whereas the encoded proteins of the three genes share highly conserved regions distinct from other bZIP families such as Jun or Fos, remaining regions diverged considerably from each other. Chromosomal localization by fluorescence insitu hybridization demonstrates that these genes are nonsyntenic. p45-NF-E2 mapped to chromosome 12q13.1–13.3, whereas Nrf1 and 2 mapped to 17q21.3 and 2q31, respectively. However, these three genes were probably derived from a single ancestor by chromosomal duplication as other genes that also map in these regions are related to one another.

Copyright information

© Springer-Verlag 1995