Medical Microbiology and Immunology

, Volume 184, Issue 3, pp 109–113

Variable degree of slime production is linked to different levels of beta-lactam susceptibility in Staphylococcus epidermidis phase variants

  • Martin Mempel
  • Edgar Müller
  • Reinhard Hoffmann
  • Hubert Feucht
  • Rainer Laufs
  • Ludwig Grüter
Original Investigation

DOI: 10.1007/BF00224346

Cite this article as:
Mempel, M., Müller, E., Hoffmann, R. et al. Med Microbiol Immunol (1995) 184: 109. doi:10.1007/BF00224346

Abstract

Recently we demonstrated that lack of mecA transcription was responsible for the decreased methicillin resistance phenotype of strongly slime-negative Staphylococcus epidermidis phase variants [Mempel M, Feucht H, Ziehbuhr W, Endres M, Laufs R, Grüter L (1994) Antimicrob Agents Chemother 38:1251–1255]. In the present study we compared the beta-lactam susceptibility and the slime production capacity of 60 phenotypic variants of S. epidermidis parent strain RP62A identified by their colony morphology on congo red agar. We could show that the variable degree of slime production is linked to different levels of β-lactam susceptibility in intermediate-stage phase variants. The increased deltahemolysin production of slime-negative phase variants may indicate an accessory gene regulator-like control.

Key words

Staphylococcus epidermidis Slime production Phase variation Deltahemolysin 

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Martin Mempel
    • 1
  • Edgar Müller
    • 1
  • Reinhard Hoffmann
    • 1
  • Hubert Feucht
    • 1
  • Rainer Laufs
    • 1
  • Ludwig Grüter
    • 1
  1. 1.Institute for Medical Microbiology and Immunology, University Hospital EppendorfHamburgGermany
  2. 2.Institute of Clinical Microbiology (Laboratory Dr. Gärtner)WeingartenGermany