Theoretical and Applied Genetics

, Volume 85, Issue 4, pp 480–488

Estimating the locations and the sizes of the effects of quantitative trait loci using flanking markers

Authors

  • O. Martínez
    • Department of Applied StatisticsUniversity of Reading
  • R. N. Curnow
    • Department of Applied StatisticsUniversity of Reading
Originals

DOI: 10.1007/BF00222330

Cite this article as:
Martínez, O. & Curnow, R.N. Theoret. Appl. Genetics (1992) 85: 480. doi:10.1007/BF00222330

Summary

The use of information from flanking markers to estimate the position and size of the effect of a quantitative trait locus (QTL) lying between two markers is shown to be affected by QTLs lying in neighbouring regions of the chromosome. In some situations the effects of two QTLs lying outside the flanked region are reinforced in such a way that a ‘ghost’ QTL may be mistakenly identified as a real QTL. These problems are discussed in the framework of a backcross using a regression model as the analytical tool to present the theoretical results. Regression models that use information obtained from three or more nearby markers are shown to be useful in separating the effects of QTLs in neighbouring regions. A simulated data set exemplifies the problem and is analysed by the interval mapping method as well as by the regression model.

Key words

Quantitative trait lociInterval mappingRFLPS mapping
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Copyright information

© Springer-Verlag 1992