Cell and Tissue Research

, Volume 243, Issue 1, pp 51–57

Sensory and autonomic innervation of non-hairy and hairy human skin

An immunohistochemical study
  • H. Björklund
  • C. -J. Dalsgaard
  • C. -E. Jonsson
  • A. Hermansson
Article

DOI: 10.1007/BF00221851

Cite this article as:
Björklund, H., Dalsgaard, C.J., Jonsson, C.E. et al. Cell Tissue Res. (1986) 243: 51. doi:10.1007/BF00221851

Summary

Non-hairy and hairy human skin were investigated with the use of the indirect immunohistochemical technique employing antisera to different neuronal and non-neuronal structural proteins and neurotransmitter candidates. Fibers immunoreactive to antisera against neurofilaments, neuron-specific enolase, myelin basic protein, protein S-100, substance P, neurokinin A, neuropeptide Y, tyrosine hydroxylase and vasoactive intestinal polypeptide (VIP) were detected in the skin with specific distributional patterns. Neurofilament-, neuron-specific enolase-, myelin basic protein-, protein S-100-, substance P-, neurokinin A-and vasoactive intestinal polypeptide (VIP)-like immunoreactivities were found in or in association with sensory nerves; moreover, neuron-specific enolase-, myelin basic protein-, protein S-100, neuropeptide Y-, tyrosine hydroxylase- and vasoactive intestinal polypeptide (VIP)-like immunoreactivities occurred in or in association with autonomic nerves. It was concluded that antiserum against neurofilaments labels sensory nerve fibers exclusively, whereas neuron-specific enolase-, myelin basic protein- and protein S-100-like immunoreactivities are found in or in association with both sensory and autonomic nerves. Substance P- and neurokinin A-like immunoreactivities were observed only in sensory nerve fibers, and neuropeptide Y- and tyrosine hydroxylase-like immunoreactivities occurred only in autonomic nerve fibers, whereas vasoactive intestinal polypeptide (VIP)-like immunoreactivity was seen predominantly in autonomic nerves, but also in some sensory nerve fibers.

Key words

SkinStructural proteinsNeuropeptide immunocytochemistrySensory nervesAutonomic innervationMan

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • H. Björklund
    • 1
    • 2
  • C. -J. Dalsgaard
    • 1
    • 2
  • C. -E. Jonsson
    • 1
    • 2
  • A. Hermansson
    • 1
    • 2
  1. 1.Departments of Histology and AnatomyKarolinska InstitutetStockholmSweden
  2. 2.Department of Plastic SurgeryKarolinska HospitalStockholmSweden
  3. 3.Department of HistologyKarolinska InstitutetStockholmSweden