Cell and Tissue Research

, Volume 185, Issue 3, pp 399–408

The effects of aging on satellite cells in skeletal muscles of mice and rats


  • Mikel H. Snow
    • Department of AnatomyUniversity of Southern California, School of Medicine

DOI: 10.1007/BF00220299

Cite this article as:
Snow, M.H. Cell Tissue Res. (1977) 185: 399. doi:10.1007/BF00220299


Myosatellite cells were examined and quantified at the fine structural level of resolution during aging of skeletal muscles in mice and rats. Satellite cells in the soleus and gastrocnemius muscles of animals between eight and 30 months of age appeared, according to morphological criteria, metabolically less active than those examined in immature muscles. In the soleus muscle of the mouse, satellite cells decreased in number from 4.6% at eight months of age to 2.4% at 30 months. This decrease appeared to be due to the passage of some satellite cells into the interstitial space as a result of the formation of external lamina material around the entire satellite cell surface.

Key words

Skeletal muscleSatellite cellsAgingRegenerationElectron microscopy

Copyright information

© Springer-Verlag 1977