Cell and Tissue Research

, Volume 190, Issue 3, pp 371–382

Filtration effect of endothelial fenestrations on chylomicron transport in neonatal rat liver sinusoids

  • M. Naito
  • E. Wisse

DOI: 10.1007/BF00219553

Cite this article as:
Naito, M. & Wisse, E. Cell Tissue Res. (1978) 190: 371. doi:10.1007/BF00219553


The function of endothelial fenestrations in the control of the passage of chylomicrons from the blood to the liver parenchymal cells was studied ultrastructurally in neonatal rats. Measurement of circulating chylomicrons and endothelial fenestrations as well as chylomicrons in the space of Disse at 2–20 h after the onset of suckling revealed a substantial filtration effect of endothelial fenestrations on chylomicrons larger than 250 nm in diameter. Direct uptake of chylomicrons by parenchymal cells was observed to occur by pinocytosis; Kupffer cells endocytosed only very few chylomicrons, and endothelial cells were inactive in this respect.

Key words

Chylomicron Liver Endothelial fenestration Space of Disse Neonate rat 

Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • M. Naito
    • 1
  • E. Wisse
    • 1
    • 2
  1. 1.Department of PathologyFukushima Medical CollegeFukushimaJapan
  2. 2.Laboratory for Electron MicroscopyLeidenThe Netherlands