Human Genetics

, Volume 91, Issue 3, pp 293–294

G6PD Mediterranean accounts for the high prevalence of G6PD deficiency in Kurdish Jews

Authors

  • Ariella Oppenheim
    • Department of HaematologyHadassah University Hospital
  • Corrine L. Jury
    • Department of HaematologyRoyal Postgraduate Medical School, Hammersmith Hospital
  • Deborah Rund
    • Department of HaematologyHadassah University Hospital
  • Tom J. Vulliamy
    • Department of HaematologyRoyal Postgraduate Medical School, Hammersmith Hospital
  • Lucio Luzzatto
    • Department of HaematologyRoyal Postgraduate Medical School, Hammersmith Hospital
Short Communications

DOI: 10.1007/BF00218277

Cite this article as:
Oppenheim, A., Jury, C.L., Rund, D. et al. Hum Genet (1993) 91: 293. doi:10.1007/BF00218277

Abstract

The Jews of Kurdistan are a small inbred population with a high incidence of β-thalassaemia and glucose-6-phosphate dehydrogenase (G6PD) deficiency. Recently, it was reported that the β-thalassaemia in this population shows an unusual mutational diversity; 13 different mutations were identified, of which 4 had not previously been observed in any other population. In contrast, we now report that the G6PD deficiency, which has the highest known incidence in the world, and which affects about 70% of males, is almost entirely attributable to a single widespread mutation, G6PD Mediterranean.

Copyright information

© Springer-Verlag 1993