Original Investigations

Human Genetics

, Volume 91, Issue 3, pp 257-260

First online:

Colocalization of the genes coding for the α3 and β3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3–q33

  • Galicia GiuiliAffiliated withInstitut National de la Santé et de la Recherche Médicale (INSERM), U-99, Hôpital Henri Mondor
  • , Nathalie RoechelAffiliated withInstitut National de la Santé et de la Recherche Médicale (INSERM), U-242, Hôpital des Enfants de la Timone
  • , Ute SchollAffiliated withInstitut National de la Santé et de la Recherche Médicale (INSERM), U-99, Hôpital Henri Mondor
  • , Marie-Geneviève MatteiAffiliated withInstitut National de la Santé et de la Recherche Médicale (INSERM), U-242, Hôpital des Enfants de la Timone
  • , Georges GuellaenAffiliated withInstitut National de la Santé et de la Recherche Médicale (INSERM), U-99, Hôpital Henri Mondor

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Abstract

We have determined the chromosomal location of the human genes coding for the α3 and β3 subunits of soluble guanylyl cyclase (GC-S). The study was performed by in situ hybridization of human metaphase spreads with two human cDNA probes, containing the coding sequences of the GC-S α3 and β3 subunits, respectively. Each probe gave a strong specific signal on chromosome 4 at the 4q31.3–4q33 region, with the maximal signal in the 4q32 band. The colocalization of both genes in 4q32 represents an interesting feature for the coordinated regulation of expression of both GC-S subunits.