Human Genetics

, Volume 91, Issue 3, pp 257–260

Colocalization of the genes coding for the α3 and β3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3–q33

Authors

  • Galicia Giuili
    • Institut National de la Santé et de la Recherche Médicale (INSERM), U-99, Hôpital Henri Mondor
  • Nathalie Roechel
    • Institut National de la Santé et de la Recherche Médicale (INSERM), U-242, Hôpital des Enfants de la Timone
  • Ute Scholl
    • Institut National de la Santé et de la Recherche Médicale (INSERM), U-99, Hôpital Henri Mondor
  • Marie-Geneviève Mattei
    • Institut National de la Santé et de la Recherche Médicale (INSERM), U-242, Hôpital des Enfants de la Timone
  • Georges Guellaen
    • Institut National de la Santé et de la Recherche Médicale (INSERM), U-99, Hôpital Henri Mondor
Original Investigations

DOI: 10.1007/BF00218267

Cite this article as:
Giuili, G., Roechel, N., Scholl, U. et al. Hum Genet (1993) 91: 257. doi:10.1007/BF00218267

Abstract

We have determined the chromosomal location of the human genes coding for the α3 and β3 subunits of soluble guanylyl cyclase (GC-S). The study was performed by in situ hybridization of human metaphase spreads with two human cDNA probes, containing the coding sequences of the GC-S α3 and β3 subunits, respectively. Each probe gave a strong specific signal on chromosome 4 at the 4q31.3–4q33 region, with the maximal signal in the 4q32 band. The colocalization of both genes in 4q32 represents an interesting feature for the coordinated regulation of expression of both GC-S subunits.

Download to read the full article text

Copyright information

© Springer-Verlag 1993