Original Investigations

Human Genetics

, Volume 90, Issue 5, pp 542-544

First online:

The human interleukin-6 receptor α chain gene is localized on chromosome 1 band q21

  • Petra M. C. KluckAffiliated withDepartment of Hematology, University Medical Center
  • , Joop WiegantAffiliated withDepartment of Cytochemistry and Cytometry, Sylvius Laboratories, University of Leiden
  • , Rumo P. M. JansenAffiliated withDepartment of Hematology, University Medical Center
  • , Marian W. J. BolkAffiliated withDepartment of Hematology, University Medical Center
  • , Anton K. RaapAffiliated withDepartment of Cytochemistry and Cytometry, Sylvius Laboratories, University of Leiden
  • , Roel WillemzeAffiliated withDepartment of Hematology, University Medical Center
  • , James E. LandegentAffiliated withDepartment of Hematology, University Medical Center

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Abstract

The human interleukin-6 receptor α chain (IL6Rα) gene was regionally mapped to chromosome 1 bridization probes, partially overlapping lambda clones encompassing 28 kb of the genomic region of the gene were used. These clones were isolated using a polymerase chain reaction (PCR)-generated fragment of the 3′ noncoding region of the gene. This localization confirms and extends the provisional assignment of the IL6Rα gene to chromosome 1, for which a panel of somatic cell hybrids was used.