Human Genetics

, Volume 89, Issue 2, pp 234–236

Localization of the human insulin-like growth-factor-binding protein 4 gene to chromosomal region 17q12–21.1

  • Svetlana Bajalica
  • Susanne V. Allander
  • Ewa Ehrenborg
  • Karen Brøndum-Nielsen
  • Holger Luthman
  • Catharina Larsson
Short Communications

DOI: 10.1007/BF00217129

Cite this article as:
Bajalica, S., Allander, S.V., Ehrenborg, E. et al. Hum Genet (1992) 89: 234. doi:10.1007/BF00217129

Summary

Insulin-like growth-factor-binding proteins (IGFBPs) constitute a family of structurally related proteins that specifically bind insulin-like growth factors and modulate their functions. In this study, the chromosomal localization was determined for the gene encoding IGFBP4, i.e. inhibitory-IGFBP. A polymerase chain reaction (PCR) fragment corresponding to the previously published cDNA sequence was used to isolate overlapping cosmid clones. By fluorescent in situ hybridization to metaphase chromosomes, the IGFBP4 gene was then localized to chromosomal region 17q21–21.1. This result was in agreement with PCR analysis of a panel of somatic cell hybrids.

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Svetlana Bajalica
    • 1
  • Susanne V. Allander
    • 1
  • Ewa Ehrenborg
    • 1
  • Karen Brøndum-Nielsen
    • 2
  • Holger Luthman
    • 1
  • Catharina Larsson
    • 1
  1. 1.Department of Clinical GeneticsKarolinska HospitalStockholmSweden
  2. 2.Department of Medical GeneticsOdense UniversityOdenseDenmark