Original Investigations

Human Genetics

, Volume 92, Issue 5, pp 477-480

First online:

Diverse polymorphism within a short coding region of the human aldehyde dehydrogenase-5 (ALDH5) gene

  • David ShermanAffiliated withDepartment of Clinical Biochemistry, King's College School of Medicine and Dentistry
  • , Vibha DavéAffiliated withDepartment of Biochemical Genetics, Beckman Research Institute of the City of Hope
  • , Lily C. HsuAffiliated withDepartment of Biochemical Genetics, Beckman Research Institute of the City of Hope
  • , Timothy J. PetersAffiliated withDepartment of Clinical Biochemistry, King's College School of Medicine and Dentistry
  • , Akira YoshidaAffiliated withDepartment of Biochemical Genetics, Beckman Research Institute of the City of Hope

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Abstract

Human aldehyde dehydrogenase-5 gene (originally named as ALDHX) is expressed in liver and testis. The ALDH5 does not contain introns in the coding sequence for 517 amino acid residues. Within a short nucleotide region of the gene, the following three nucleotide changes were found in high frequencies, i.e., a silent C↔T at nucleotide (nt) 183, C↔T at nt 257 associated with a Val↔Ala substitution, and T↔G at nt 320 associated with a Arg↔Leu substitution. The frequency of C at nt 183 is 81% in Caucasians and 65% in Japanese, and the difference is statistically not significant. The frequency of C at nt 257 is 76% in Caucasians and 55% in Japanese, and the difference is statistically significant (P = 0.02). The frequency of T at nt 320 is 71% in Caucasians, while it is only 27% in Japanese. The racial difference at nt 320 is highly significant (P < 0.001). No significant difference was found in the genotypes of the three nucleotide positions between alcoholic and nonalcoholic Caucasians within the limited numbers of subjects examined.